Endocrine Abstracts

Background: Elevated low-density lipoprotein cholesterol (LDL-C), which arises due to genetic and environmental factors, has a causal role in the pathogenesis of cardiovascular disease (CVD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are approved for patients with familial hypercholesterolaemia (FH) and patients at high risk of CVD due to non-familial hypercholesterolaemia (non-FH). In clinical trials, PCSK9 inhibitors are well-tolerated and lead to redu...

Background: At the beginning of the first Covid 19 lockdown the team realized the need for an innovative way of having contact with young people. Virtual sessions could do this? We also needed to meet young person’s wishes.Objectives: -For the activity to be fun. -Improve carbohydrate counting, knowledge, expertise and confidence -Give young people skills to be independent with their carb counting skills...

Background: Studies suggest that glucocorticoid hypersecretion alongside primary hyperaldosteronism (PA) is common and may contribute to the adverse metabolic phenotype. Adrenal crisis post-surgery for PA is rare.Aim: To determine the prevalence of cortisol co-secretion in PA in patients at Imperial College London NHS Trust, Hammersmith Hospital (a tertiary referral centre for adrenal tumours).Methods: Am...

Background: Studies suggest that glucocorticoid hypersecretion alongside primary hyperaldosteronism (PA) is common and may contribute to the adverse metabolic phenotype. Adrenal crisis post-surgery for PA is rare.Aim: To determine the prevalence of cortisol co-secretion in PA in patients at Imperial College London NHS Trust, Hammersmith Hospital (a tertiary referral centre for adrenal tumours).Methods: Am...

Alzheimer’s disease is a progressive disease of the human brain characterized by memory impairment and disturbance in at least one other thinking function. Type 2 diabetes (T2D) is the kind of diabetes mellitus (DM) that occurs due to the absence or deficiency of insulin receptors and it is usually referred to as maturity-onset DM. The hippocampus, and frontal area of the brain are areas with receptors for insulin, meaning that the hippocampus structure is majorly damaged...

The amount of radioactivity given to patients undergoing ablation for remnant tissue in thyroid cancer at our centre has been greatly reduced to 1100 MBq I-131 in recent years, prompting a review of practice. An extensive risk assessment, focusing particularly on radiation exposure to the public during the patient’s commute home was conducted and found patients could now be discharged safely on the day of treatment. Owing to these findings and audit showing 86% of patient...

Case History: This is a 73 year old lady with known Type 2 Diabetes Mellitus who presented to Acute Medicine with a 2-week history of diarrhoea and acute confusion on a background of a 4-month history of gradual cognitive and functional decline. She was treated for low-respiratory tract infection with acute kidney injury on a background of age-related functional decline. CT brain was organised.Investigations: CT Brain: Large enhancing soft tissue dense l...

Aims: To evaluate the prevalence of antinuclear antibodies (ANA) in patients with chronic autoimmune thyroiditis (CAT) associated with periodontal disease (P.D).Material and methods: 42 patients with TCA and BP were tested for ANA (Group 1) and 50 patients with TCA without BP (Group 2). Inclusion criterias – absence of other autoimmune diseases associated with positive ANA patients. Thyroid hormone deficiency has established thyroid function. Patien...

The factors responsible for regulating primordial follicle activation and early preantral follicle growth remain poorly understood, despite their importance in determining a female’s reproductive lifespan. The essential role of the epidermal growth factor (EGF) family of receptors (ErbBs) during ovulation is well established; however there is emerging evidence that ErbBs may also be important regulators of early follicle development. This study aimed to investigate the ro...

Introduction: Recent evidence supports the use of high dose steroids for 28 days in acute alcoholic hepatitis. We present a patient with Childs Pugh C liver cirrhosis, who developed adrenal axis suppression following such treatment. We discuss the complex aetiology and biochemistry of hypocortisolism in liver disease.Case: 48 year-old female admitted with alcoholic hepatitis, treated with a non-tapering 28-day course of 40 mg prednisolone. The patient wa...